Absence of Acute Inhibitory Effect of Insulin on Chylomicron Production in Type 2 Diabetes | Zendy

Juan Patricio Nogueira | Zendy; Marie Maraninchi | Zendy; Sophie Béliard | Zendy; Nadège Padilla | Zendy; Laurence Duvillard | Zendy; Julien Mancini | Zendy; Alain Nicolay | Zendy; Changting Xiao | Zendy; B. Vialettes | Zendy; Gary F. Lewis | Zendy; René Valéro | Zendy

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Absence of Acute Inhibitory Effect of Insulin on Chylomicron Production in Type 2 Diabetes

Author(s) -

Juan Patricio Nogueira,

Marie Maraninchi,

Sophie Béliard,

Nadège Padilla,

Laurence Duvillard,

Julien Mancini,

Alain Nicolay,

Changting Xiao,

B. Vialettes,

Gary F. Lewis,

René Valéro

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.242073

Subject(s) - medicine , endocrinology , chylomicron , type 2 diabetes , hyperinsulinemia , glucose clamp technique , apolipoprotein b , insulin , diabetes mellitus , lipoprotein , biology , insulin resistance , very low density lipoprotein , cholesterol , pancreatic hormone

Overproduction of intestinally derived apoB-48-containing triglyceride-rich lipoproteins (TRLs) (chylomicrons) has recently been described in type 2 diabetes, as is known for hepatic TRL-apoB-100 (very-low-density lipoprotein) production. Furthermore, insulin acutely inhibits both intestinal and hepatic TRL production, whereas this acute inhibitory effect on very-low-density lipoprotein production is blunted in type 2 diabetes. It is not currently known whether this acute effect on chylomicron production is similarly blunted in humans with type 2 diabetes.

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