A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content | Zendy

Martina A. McAteer | Zendy; Kulveer Mankia | Zendy; Neil Ruparelia | Zendy; Andrew Jefferson | Zendy; Hannah B. Nugent | Zendy; LeeAnne Stork | Zendy; Keith M. Chan | Zendy; Jürgen E. Schneider | Zendy; Robin P. Choudhury | Zendy

Open Access

A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content

Author(s) -

Martina A. McAteer,

Kulveer Mankia,

Neil Ruparelia,

Andrew Jefferson,

Hannah B. Nugent,

LeeAnne Stork,

Keith M. Chan,

Jürgen E. Schneider,

Robin P. Choudhury

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.241844

Subject(s) - inflammation , magnetic resonance imaging , in vivo , flow cytometry , chemistry , endothelial stem cell , preclinical imaging , endothelium , pathology , microbiology and biotechnology , medicine , immunology , biology , in vitro , biochemistry , radiology

Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression.

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