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Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression.

arteriosclerosis, thrombosis, and vascular biology

A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content