Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats | Zendy

Yuh Fen Pung | Zendy; Petra Ročić | Zendy; Michael P. Murphy | Zendy; Robin A.J. Smith | Zendy; Jennifer L Hafemeister | Zendy; Vahagn Ohanyan | Zendy; G Guarini | Zendy; Liya Yin | Zendy; William M. Chilian | Zendy

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Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats

Author(s) -

Yuh Fen Pung,

Petra Ročić,

Michael P. Murphy,

Robin A.J. Smith,

Jennifer L Hafemeister,

Vahagn Ohanyan,

G Guarini,

Liya Yin,

William M. Chilian

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.241802

Subject(s) - oxidative stress , medicine , endocrinology , reactive oxygen species , mitochondrion , oxidative phosphorylation , mitochondrial ros , chemistry , glutathione peroxidase , biology , catalase , biochemistry

We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting dysfunction and also show increased production of O(2), we hypothesized that mitochondrial dysfunction caused by oxidative stress impairs coronary collateral growth in ZOF.

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