Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice | Zendy

Michael M. Weinstein | Zendy; Chris N. Goulbourne | Zendy; Brandon S.J. Davies | Zendy; Yiping Tu | Zendy; Richard H. Barnes | Zendy; Steven M. Watkins | Zendy; Ryan M. Davis | Zendy; Karen Reue | Zendy; Peter Tontonoz | Zendy; Anne P. Beigneux | Zendy; Loren G. Fong | Zendy; Stephen G. Young | Zendy

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Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice

Author(s) -

Michael M. Weinstein,

Chris N. Goulbourne,

Brandon S.J. Davies,

Yiping Tu,

Richard H. Barnes,

Steven M. Watkins,

Ryan M. Davis,

Karen Reue,

Peter Tontonoz,

Anne P. Beigneux,

Loren G. Fong,

Stephen G. Young

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.241406

Subject(s) - reciprocal , adipose tissue , endocrinology , medicine , microbiology and biotechnology , biology , philosophy , linguistics

Gpihbp1-deficient (Gpihbp1-/-) mice lack the ability to transport lipoprotein lipase to the capillary lumen, resulting in mislocalization of lipoprotein lipase within tissues, defective lipolysis of triglyceride-rich lipoproteins, and chylomicronemia. We asked whether GPIHBP1 deficiency and mislocalization of catalytically active lipoprotein lipase would alter the composition of triglycerides in adipose tissue or perturb the expression of lipid biosynthetic genes. We also asked whether perturbations in adipose tissue composition and gene expression, if they occur, would be accompanied by reciprocal metabolic changes in the liver.

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