Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells | Zendy

Fang Wang | Zendy; Ying Wang | Zendy; Dahai Zhang | Zendy; Prasanth Puthanveetil | Zendy; James D. Johnson | Zendy; Brian Rodrigues | Zendy

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Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells

Author(s) -

Fang Wang,

Ying Wang,

Dahai Zhang,

Prasanth Puthanveetil,

James D. Johnson,

Brian Rodrigues

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.240770

Subject(s) - chromosomal translocation , metabolism , carbohydrate metabolism , fatty acid metabolism , chemistry , lipid metabolism , biochemistry , heparanase , fatty acid , cellular metabolism , microbiology and biotechnology , biology , cell , gene , heparan sulfate

Heparanase is an endoglycosidase that specifically cleaves carbohydrate chains of heparan sulfate. We have recently reported that high fatty acid increased the nuclear content of endothelial heparanase. Here, we examined the mechanism and the consequences behind this nuclear translocation of heparanase.

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