Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor | Zendy

Shamshad J. Sherajee | Zendy; Yoshiko Fujita | Zendy; Kazi Rafiq | Zendy; Daisuke Nakano | Zendy; Hirohito Mori | Zendy; Tsutomu Masaki | Zendy; Taiga Hara | Zendy; Masakazu Kohno | Zendy; Akira Nishiyama | Zendy; Hirofumi Hitomi | Zendy

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Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor

Author(s) -

Shamshad J. Sherajee,

Yoshiko Fujita,

Kazi Rafiq,

Daisuke Nakano,

Hirohito Mori,

Tsutomu Masaki,

Taiga Hara,

Masakazu Kohno,

Akira Nishiyama,

Hirofumi Hitomi

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.240697

Subject(s) - endocrinology , mineralocorticoid receptor , medicine , insulin like growth factor 1 receptor , aldosterone , insulin receptor , insulin resistance , eplerenone , insulin , mineralocorticoid , receptor , biology , chemistry , growth factor

We previously showed that aldosterone induces insulin resistance in rat vascular smooth muscle cells (VSMCs). Because insulin-like growth factor-1 receptor (IGF1R) affects insulin signaling, we hypothesized that aldosterone induces vascular insulin resistance and remodeling via upregulation of IGF1R and its hybrid insulin/insulin-like growth factor-1 receptor.

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