Accelerated Atherosclerosis in  Apoe −/−  Mice Heterozygous for the Insulin Receptor and the Insulin Receptor Substrate-1 | Zendy

Elena Galkina | Zendy; Matthew Butcher | Zendy; Susanna R. Keller | Zendy; Matthew Goff | Zendy; Anthony C. Bruce | Zendy; Hong Pei | Zendy; Ian J. Sarembock | Zendy; John M. Sanders | Zendy; Melissa H. Nagelin | Zendy; Suseela Srinivasan | Zendy; Rohit Kulkarni | Zendy; Catherine C. Hedrick | Zendy; Frank A. Lattanzio | Zendy; Anca D. Dobrian | Zendy; Jerry L. Nadler | Zendy; Klaus Ley | Zendy

Open Access

Accelerated Atherosclerosis in Apoe ^−/− Mice Heterozygous for the Insulin Receptor and the Insulin Receptor Substrate-1

Author(s) -

Elena Galkina,

Matthew Butcher,

Susanna R. Keller,

Matthew Goff,

Anthony C. Bruce,

Hong Pei,

Ian J. Sarembock,

John M. Sanders,

Melissa H. Nagelin,

Suseela Srinivasan,

Rohit Kulkarni,

Catherine C. Hedrick,

Frank A. Lattanzio,

Anca D. Dobrian,

Jerry L. Nadler,

Klaus Ley

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.240358

Subject(s) - insulin receptor , medicine , irs1 , endocrinology , insulin , apolipoprotein e , hyperinsulinemia , insulin receptor substrate , insulin resistance , irs2 , biology , disease

Prediabetic states are associated with accelerated atherosclerosis, but the availability of mouse models to study connections between these diseases has been limited. The aim of this study was to test the selective role of impaired insulin receptor/insulin receptor substrate-1 signaling on atherogenesis.

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