Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis | Zendy

Omar Saeed | Zendy; Fumiyuki Otsuka | Zendy; Rohini Polavarapu | Zendy; Vinit Karmali | Zendy; Daiana Weiss | Zendy; Talina Davis | Zendy; Brad Rostad | Zendy; Kimberly Pachura | Zendy; Lila Adams | Zendy; J. Elliott | Zendy; W. Robert Taylor | Zendy; Jagat Narula | Zendy; Frank D. Kolodgie | Zendy; Renu Virmani | Zendy; Charles C. Hong | Zendy; Aloke V. Finn | Zendy

Open Access

Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis

Author(s) -

Omar Saeed,

Fumiyuki Otsuka,

Rohini Polavarapu,

Vinit Karmali,

Daiana Weiss,

Talina Davis,

Brad Rostad,

Kimberly Pachura,

Lila Adams,

J. Elliott,

W. Robert Taylor,

Jagat Narula,

Frank D. Kolodgie,

Renu Virmani,

Charles C. Hong,

Aloke V. Finn

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.240101

Subject(s) - foam cell , efflux , macrophage , hepcidin , inflammation , cholesterol , chemistry , microbiology and biotechnology , abca1 , endocrinology , medicine , immunology , biology , biochemistry , in vitro , transporter , gene

We recently reported that lowering of macrophage free intracellular iron increases expression of cholesterol efflux transporters ABCA1 and ABCG1 by reducing generation of reactive oxygen species. In this study, we explored whether reducing macrophage intracellular iron levels via pharmacological suppression of hepcidin can increase macrophage-specific expression of cholesterol efflux transporters and reduce atherosclerosis.

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