ApoE Suppresses Atherosclerosis by Reducing Lipid Accumulation in Circulating Monocytes and the Expression of Inflammatory Molecules on Monocytes and Vascular Endothelium | Zendy

Nathalie Gaudreault | Zendy; Nikit Kumar | Zendy; Jessica M. Posada | Zendy; Kyle Stephens | Zendy; Nabora Soledad Reyes de Mochel | Zendy; Delphine Eberlé | Zendy; Victor Olivas | Zendy; Roy Kim | Zendy; Matthew Harms | Zendy; Sean Johnson | Zendy; Louis M. Messina | Zendy; Joseph H. Rapp | Zendy; Robert L. Raffaı̈ | Zendy

Open Access

ApoE Suppresses Atherosclerosis by Reducing Lipid Accumulation in Circulating Monocytes and the Expression of Inflammatory Molecules on Monocytes and Vascular Endothelium

Author(s) -

Nathalie Gaudreault,

Nikit Kumar,

Jessica M. Posada,

Kyle Stephens,

Nabora Soledad Reyes de Mochel,

Delphine Eberlé,

Victor Olivas,

Roy Kim,

Matthew Harms,

Sean Johnson,

Louis M. Messina,

Joseph H. Rapp,

Robert L. Raffaı̈

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.238964

Subject(s) - apolipoprotein e , apolipoprotein b , ldl receptor , endocrinology , medicine , hyperlipidemia , lipoprotein , cholesterol , monocyte , proinflammatory cytokine , inflammation , endothelium , biology , chemistry , diabetes mellitus , disease

We investigated atheroprotective properties of apolipoprotein (apo) E beyond its ability to lower plasma cholesterol. We hypothesized that apoE reduces atherosclerosis by decreasing lipid accumulation in circulating monocytes and the inflammatory state of monocytes and the vascular endothelium.

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