In Vivo Functional and Transcriptional Profiling of Bone Marrow Stem Cells After Transplantation Into Ischemic Myocardium | Zendy

Ahmad Y. Sheikh | Zendy; Bruno Hüber | Zendy; Kazim Narsinh | Zendy; Joshua M. Spin | Zendy; Koen van der Bogt | Zendy; Patricia E. de Almeida | Zendy; Katherine J. Ransohoff | Zendy; Daniel Kraft | Zendy; Giovanni Fajardo | Zendy; Diego Ardigò | Zendy; Julia D. Ransohoff | Zendy; Daniel Bernstein | Zendy; Michael P. Fischbein | Zendy; Robert C. Robbins | Zendy; Joseph C. Wu | Zendy

Open Access

In Vivo Functional and Transcriptional Profiling of Bone Marrow Stem Cells After Transplantation Into Ischemic Myocardium

Author(s) -

Ahmad Y. Sheikh,

Bruno Hüber,

Kazim Narsinh,

Joshua M. Spin,

Koen van der Bogt,

Patricia E. de Almeida,

Katherine J. Ransohoff,

Daniel Kraft,

Giovanni Fajardo,

Diego Ardigò,

Julia D. Ransohoff,

Daniel Bernstein,

Michael P. Fischbein,

Robert C. Robbins,

Joseph C. Wu

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.238618

Subject(s) - transcriptome , transplantation , downregulation and upregulation , bioluminescence imaging , bone marrow , in vivo , stem cell , cell therapy , cancer research , medicine , stem cell therapy , cell , gene expression profiling , myocardial infarction , biology , pathology , microbiology and biotechnology , gene expression , cardiology , gene , transfection , biochemistry , genetics , luciferase

Clinical trials of bone marrow-derived stem cell therapy for the heart have yielded variable results. The basic mechanism(s) that underlies their potential efficacy remains unknown. In the present study, we evaluated the survival kinetics, transcriptional response, and functional outcome of intramyocardial bone marrow mononuclear cell (BMMC) transplantation for cardiac repair in a murine myocardial infarction model.

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