Overexpression of Tissue Inhibitor of Metalloproteinase 3 in Macrophages Reduces Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice | Zendy

Viviana Casagrande | Zendy; Rossella Menghini | Zendy; Stefano Menini | Zendy; Arianna Marino | Zendy; Valentina Marchetti | Zendy; Michele Cavalera | Zendy; Marta Fabrizi | Zendy; Marta Letizia Hribal | Zendy; Giuseppe Pugliese | Zendy; Paolo Gentileschi | Zendy; Orazio Schillaci | Zendy; Ottavia Porzio | Zendy; Davide Lauro | Zendy; Paolo Sbraccia | Zendy; Renato Lauro | Zendy; Massimo Federici | Zendy

Open Access

Overexpression of Tissue Inhibitor of Metalloproteinase 3 in Macrophages Reduces Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice

Author(s) -

Viviana Casagrande,

Rossella Menghini,

Stefano Menini,

Arianna Marino,

Valentina Marchetti,

Michele Cavalera,

Marta Fabrizi,

Marta Letizia Hribal,

Giuseppe Pugliese,

Paolo Gentileschi,

Orazio Schillaci,

Ottavia Porzio,

Davide Lauro,

Paolo Sbraccia,

Renato Lauro,

Massimo Federici

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.238402

Subject(s) - ldl receptor , macrophage , knockout mouse , inflammation , receptor , monocyte , chemistry , endocrinology , medicine , foam cell , lipoprotein , oxidative stress , biology , cholesterol , biochemistry , in vitro

Tissue inhibitor of metalloproteinase 3 (TIMP3) is a stromal protein that inhibits the activity of proteases and receptors. TIMP3 is downregulated in metabolic and inflammatory disorders, such as type 2 diabetes mellitus and atherosclerosis, particularly in regions enriched with monocyte/macrophage cells. To investigate the role of TIMP3 in atherosclerosis, we generated a new mouse model in which Timp3 was overexpressed in the atherosclerotic plaque via a macrophage-specific promoter (MacT3). We elucidated any potential antiatherosclerotic effects of TIMP3, including regulation of monocyte/macrophage recruitment within atherosclerotic plaques, in MacT3 mice crossbred with low-density lipoprotein receptor knockout (LDLR(-/-)) mice.

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