Factor VII–Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor | Zendy

Sandip M. Kanse | Zendy; Paul Declerck | Zendy; Wolfram Ruf | Zendy; George Broze | Zendy; Michael Etscheid | Zendy

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Factor VII–Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor

Author(s) -

Sandip M. Kanse,

Paul Declerck,

Wolfram Ruf,

George Broze,

Michael Etscheid

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.238394

Subject(s) - proteolysis , tissue factor , protease , tissue factor pathway inhibitor , protease inhibitor (pharmacology) , microbiology and biotechnology , biology , chemistry , biochemistry , enzyme , medicine , immunology , coagulation , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load

Factor VII-activating protease (FSAP) activates both factor VII and pro-urokinase and inhibits platelet-derived growth factor-BB, thus regulating hemostasis- and remodeling-associated processes in the vasculature. A genetic variant of FSAP (Marburg I polymorphism) results in low enzymatic activity and is associated with an enhanced risk of carotid stenosis and stroke. We postulate that there are additional substrates for FSAP that will help to explain its role in vascular biology and have searched for such a substrate.

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