Crucial Role of CD40 Signaling in Vascular Wall Cells in Neointimal Formation and Vascular Remodeling After Vascular Interventions | Zendy

Zifang Song | Zendy; Rong Jin | Zendy; Shiyong Yu | Zendy; Anil Nanda | Zendy; D. Neil Granger | Zendy; Guohong Li | Zendy

Open Access

Crucial Role of CD40 Signaling in Vascular Wall Cells in Neointimal Formation and Vascular Remodeling After Vascular Interventions

Author(s) -

Zifang Song,

Rong Jin,

Shiyong Yu,

Anil Nanda,

D. Neil Granger,

Guohong Li

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.238329

Subject(s) - proinflammatory cytokine , cd40 , tumor necrosis factor alpha , downregulation and upregulation , bone marrow , monocyte , inflammation , microbiology and biotechnology , chemistry , cancer research , medicine , endocrinology , in vitro , biology , biochemistry , cytotoxic t cell , gene

It has been shown that CD40-TRAF6 axis in leukocytes plays a significant role in neointimal formation after carotid ligation. Because CD40 and TRAF6 are expressed not only in leukocytes but also in vascular cells, we examined the role of CD40 contributed by vascular wall cells in neointimal formation after carotid ligation in an atherogenic environment.

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