Open AccessMicroRNA Regulation of Cardiovascular Functions
Author(s) -
William C. Sessa
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.111.238311
Subject(s) - microrna , gene silencing , drosha , biology , dicer , vascular smooth muscle , three prime untranslated region , messenger rna , untranslated region , gene expression , rna interference , regulation of gene expression , microbiology and biotechnology , computational biology , bioinformatics , gene , rna , genetics , endocrinology , smooth muscle
In the past decade, microRNAs (miRNA) have emerged as important regulators of posttranscriptional gene regulation, thereby “fine-tuning” the levels of gene expression during development and stress. miRNA are 22-nucleotide RNA molecules that are derived from intronic, exonic, or pseudogenic DNA. miRNA is processed by the enzymes Drosha and Dicer and can hybridize to the 3′-untranslated region of mRNA loaded onto the RNA-induced silencing complex. miRNA can then regulate mRNA and protein levels by promoting RNA decay or interfering with mRNA translation into protein. In the cardiovascular system, miRNA have been profiled …
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