Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis | Zendy

Cameron S. McAlpine | Zendy; Anna J. Bowes | Zendy; Mohammad I. Khan | Zendy; Yuanyuan Shi | Zendy; Geoff H. Werstuck | Zendy

Open Access

Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis

Author(s) -

Cameron S. McAlpine,

Anna J. Bowes,

Mohammad I. Khan,

Yuanyuan Shi,

Geoff H. Werstuck

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.237941

Subject(s) - endoplasmic reticulum , gsk 3 , glycogen synthase , unfolded protein response , apolipoprotein b , chemistry , glycogen , kinase , medicine , microbiology and biotechnology , endocrinology , biology , cholesterol

The goal of this study was to examine the role of endoplasmic reticulum (ER) stress signaling and the contribution of glycogen synthase kinase (GSK)-3β activation in hyperglycemic, hyperhomocysteinemic, and high-fat-fed apolipoprotein E-deficient (apoE(-/-)) mouse models of accelerated atherosclerosis.

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