Notch3 Arg170Cys Knock-In Mice Display Pathologic and Clinical Features of the Neurovascular Disorder Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy | Zendy

Goedele Wallays | Zendy; Dieter Nuyens | Zendy; Robert SilasiMansat | Zendy; Joris Souffreau | Zendy; Zsuzsanna CallaertsVegh | Zendy; An Van Nuffelen | Zendy; Lieve Moons | Zendy; Rudi D’Hooge | Zendy; Florea Lupu | Zendy; Peter Carmeliet | Zendy; Désiré Collen | Zendy; Mieke Dewerchin | Zendy

Open Access

Notch3 Arg170Cys Knock-In Mice Display Pathologic and Clinical Features of the Neurovascular Disorder Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Author(s) -

Goedele Wallays,

Dieter Nuyens,

Robert SilasiMansat,

Joris Souffreau,

Zsuzsanna CallaertsVegh,

An Van Nuffelen,

Lieve Moons,

Rudi D’Hooge,

Florea Lupu,

Peter Carmeliet,

Désiré Collen,

Mieke Dewerchin

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.237859

Subject(s) - cadasil , leukoencephalopathy , pathology , medicine , gliosis , neurovascular bundle , pathogenesis , stroke (engine) , neuroscience , disease , biology , mechanical engineering , engineering

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult-onset neurovascular disorder caused by stereotyped mutations in the NOTCH3 receptor. Elucidation of its pathobiology is still incomplete and remains a challenge, in part because the available preclinical mouse models to date do not reproduce the full spectrum of CADASIL pathology and clinical disease.

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