ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion | Zendy

Jolanta M. SillerMatula | Zendy; Yahye Merhi | Zendy; JeanFrançois Tanguay | Zendy; Daniel Duerschmied | Zendy; Denisa D. Wagner | Zendy; Kathleen E. McGinness | Zendy; P. Shan Pendergrast | Zendy; Jou-Ku Chung | Zendy; Xianbin Tian | Zendy; Robert G. Schaub | Zendy; Bernd Jilma | Zendy

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ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion

Author(s) -

Jolanta M. SillerMatula,

Yahye Merhi,

JeanFrançois Tanguay,

Daniel Duerschmied,

Denisa D. Wagner,

Kathleen E. McGinness,

P. Shan Pendergrast,

Jou-Ku Chung,

Xianbin Tian,

Robert G. Schaub,

Bernd Jilma

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.237529

Subject(s) - von willebrand factor , platelet adhesion , antagonist , platelet activation , platelet , pharmacology , chemistry , platelet adhesiveness , medicine , platelet aggregation , receptor , biochemistry

We investigated the stability, pharmacokinetic, and pharmacodynamic profile of the 2(nd) generation anti-von Willeband factor aptamer ARC15105.

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