Geranylgeranylacetone, Heat Shock Protein 90/AMP-Activated Protein Kinase/Endothelial Nitric Oxide Synthase/Nitric Oxide Pathway, and Endothelial Function in Humans | Zendy

Noritaka Fujimura | Zendy; Daisuke Jitsuiki | Zendy; Tatsuya Maruhashi | Zendy; Shinsuke Mikami | Zendy; Yumiko Iwamoto | Zendy; Masato Kajikawa | Zendy; Kazuaki Chayama | Zendy; Yasuki Kihara | Zendy; Kensuke Noma | Zendy; Chikara Goto | Zendy; Yukihito Higashi | Zendy

Open Access

Geranylgeranylacetone, Heat Shock Protein 90/AMP-Activated Protein Kinase/Endothelial Nitric Oxide Synthase/Nitric Oxide Pathway, and Endothelial Function in Humans

Author(s) -

Noritaka Fujimura,

Daisuke Jitsuiki,

Tatsuya Maruhashi,

Shinsuke Mikami,

Yumiko Iwamoto,

Masato Kajikawa,

Kazuaki Chayama,

Yasuki Kihara,

Kensuke Noma,

Chikara Goto,

Yukihito Higashi

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.237263

Subject(s) - enos , protein kinase b , hsp90 , nitric oxide , nitric oxide synthase , ampk , heat shock protein , endothelial dysfunction , protein kinase a , sodium nitroprusside , endothelial nos , endocrinology , medicine , nitric oxide synthase type iii , vasodilation , chemistry , phosphorylation , biochemistry , gene

Geranylgeranylacetone (GGA) induces expression of heat shock protein 90 (Hsp90), an adaptor molecule for assembly of endothelial nitric oxide synthase (eNOS) phosphorylation complex. The purpose of this study was to determine whether GGA enhances Hsp90 expression and augments endothelium-dependent vasodilation via upregulation of eNOS in humans.

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