Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo | Zendy

Mathew J. Jenkins | Zendy; Amanda J. Edgley | Zendy; Takashi Sonobe | Zendy; Keiji Umetani | Zendy; Daryl O. Schwenke | Zendy; Yutaka Fujii | Zendy; Russell D. Brown | Zendy; Darren J. Kelly | Zendy; Mikiyasu Shirai | Zendy; James T. Pearson | Zendy

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Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo

Author(s) -

Mathew J. Jenkins,

Amanda J. Edgley,

Takashi Sonobe,

Keiji Umetani,

Daryl O. Schwenke,

Yutaka Fujii,

Russell D. Brown,

Darren J. Kelly,

Mikiyasu Shirai,

James T. Pearson

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.237172

Subject(s) - microvessel , medicine , in vivo , microcirculation , vasodilation , cardiology , diabetes mellitus , endothelium , nitric oxide , endothelial dysfunction , prostacyclin , endocrinology , angiogenesis , biology , microbiology and biotechnology

In diabetes, long-term micro- and macrovascular damage often underlies the functional decline in the cardiovascular system. However, it remains unclear whether early-stage diabetes is associated with in vivo functional impairment in the coronary microvasculature. Synchrotron imaging allows us to detect and quantify regional differences in resistance microvessel caliber in vivo, even under conditions of high heart rate.

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