Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism | Zendy

José J. Fuster | Zendy; Herminia GonzálezNavarro | Zendy; Ángela Vinué | Zendy; Pedro Molina-Sánchez | Zendy; María J. AndrésManzano | Zendy; Keiichi I. Nakayama | Zendy; Keiko Nakayama | Zendy; Antonio Dı́ez-Juan | Zendy; António Bernad | Zendy; Cristina Rodrı́guez | Zendy; José MartínezGonzález | Zendy; Vicente Andrés | Zendy

Open Access

Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism

Author(s) -

José J. Fuster,

Herminia GonzálezNavarro,

Ángela Vinué,

Pedro Molina-Sánchez,

María J. AndrésManzano,

Keiichi I. Nakayama,

Keiko Nakayama,

Antonio Dı́ez-Juan,

António Bernad,

Cristina Rodrı́guez,

José MartínezGonzález,

Vicente Andrés

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.235580

Subject(s) - foam cell , phosphorylation , mechanism (biology) , serine , macrophage , microbiology and biotechnology , cell growth , chemistry , biology , biochemistry , physics , quantum mechanics , in vitro

Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atherosclerosis coinciding with enhanced arterial cell proliferation. However, it is unknown whether molecular mechanisms that limit p27's protective function contribute to atherosclerosis development and whether p27 exerts proliferation-independent activities in the arterial wall. This study aims to provide insight into both questions by investigating the role in atherosclerosis of p27 phosphorylation at serine 10 (p27-phospho-Ser10), a major posttranslational modification of this protein.

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