The Scaffolding Protein EBP50 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Regulating Skp2 and p21 cip1 | Zendy

Gyun Jee Song | Zendy; Stacey Barrick | Zendy; Kristen Leslie | Zendy; Philip M. Bauer | Zendy; Verónica Alonso | Zendy; Peter A. Friedman | Zendy; Nathalie FiaschiTaesch | Zendy; Alessandro Bisello | Zendy

Open Access

The Scaffolding Protein EBP50 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Regulating Skp2 and p21 ^cip1

Author(s) -

Gyun Jee Song,

Stacey Barrick,

Kristen Leslie,

Philip M. Bauer,

Verónica Alonso,

Peter A. Friedman,

Nathalie FiaschiTaesch,

Alessandro Bisello

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.235200

Subject(s) - neointima , vascular smooth muscle , cell growth , microbiology and biotechnology , kinase , cell cycle , rhoa , chemistry , protein kinase b , apoptosis , biology , phosphorylation , endocrinology , medicine , signal transduction , biochemistry , restenosis , smooth muscle , stent

The Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is a scaffolding protein known to regulate ion homeostasis in the kidney and intestine. Previous work showed that EBP50 expression increases after balloon injury in rat carotids. This study was designed to determine the role of EBP50 on vascular smooth muscle cells (VSMC) proliferation and the development of neointimal hyperplasia.

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