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Nucleotide-binding oligomerization domain protein 2 (NOD2) stimulates diverse inflammatory responses resulting in differential cellular phenotypes. To identify the role of NOD2 in vascular arterial obstructive diseases, we investigated the expression and pathophysiological role of NOD2 in a vascular injury model of neointimal hyperplasia.

Nucleotide-Binding Oligomerization Domain Protein 2 Deficiency Enhances Neointimal Formation in Response to Vascular Injury