Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice | Zendy

Jiusong Sun | Zendy; Galina K. Sukhova | Zendy; Jie Zhang | Zendy; Han Chen | Zendy; Sara Sjöberg | Zendy; Peter Libby | Zendy; Mingcan Xia | Zendy; Na Xiong | Zendy; Bruce D. Gelb | Zendy; GuoPing Shi | Zendy

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Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

Author(s) -

Jiusong Sun,

Galina K. Sukhova,

Jie Zhang,

Han Chen,

Sara Sjöberg,

Peter Libby,

Mingcan Xia,

Na Xiong,

Bruce D. Gelb,

GuoPing Shi

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.235002

Subject(s) - elastase , perfusion , abdominal aortic aneurysm , medicine , aortic aneurysm , cathepsin , pathology , cardiology , aorta , chemistry , radiology , aneurysm , biochemistry , enzyme

Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly in AAA formation, however, remains unknown.

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