Open AccessRole for Circulating Osteogenic Precursor Cells in Aortic Valvular Disease
Author(s) -
Kevin P. Egan,
JungHoon Kim,
Emile R. Mohler,
Robert J. Pignolo
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.111.234724
Subject(s) - bone marrow , flow cytometry , immunohistochemistry , peripheral blood mononuclear cell , aortic valve , population , bone morphogenetic protein 2 , pathology , heart valve , haematopoiesis , biology , medicine , microbiology and biotechnology , immunology , stem cell , in vitro , biochemistry , environmental health
Approximately 13% of aortic valves removed from patients with end-stage aortic valve disease contain heterotopic ossification (HO). Recently, we identified a novel population of circulating osteogenic precursor (COP) cells that are derived from bone marrow and have the capability to form bone. These cells are identified by coexpression of the osteogenic marker type 1 collagen or osteoclacin and the hematopoietic marker CD45. We tested the hypothesis that these cells may contribute to heart valve stenosis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom