Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes | Zendy

Bettina Mayer | Zendy; Markus Rehberg | Zendy; Annette Erhardt | Zendy; Alexander Wolf | Zendy; Christoph Reichel | Zendy; Michael Kracht | Zendy; Fritz Krombach | Zendy; Gisa Tiegs | Zendy; Stefan Zahler | Zendy; Angelika M. Vollmar | Zendy; Robert Fürst | Zendy

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Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes

Author(s) -

Bettina Mayer,

Markus Rehberg,

Annette Erhardt,

Alexander Wolf,

Christoph Reichel,

Michael Kracht,

Fritz Krombach,

Gisa Tiegs,

Stefan Zahler,

Angelika M. Vollmar,

Robert Fürst

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.234294

Subject(s) - xiap , microbiology and biotechnology , inflammation , inhibitor of apoptosis , signal transduction , apoptosis , tumor necrosis factor alpha , chemistry , biology , immunology , caspase , programmed cell death , biochemistry

Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NFκB signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.

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