Smooth Muscle Cholesterol Enables BK β1 Subunit-Mediated Channel Inhibition and Subsequent Vasoconstriction Evoked by Alcohol | Zendy

An. Bukiya | Zendy; Thirumalini Vaithianathan | Zendy; Guruprasad Kuntamallappanavar | Zendy; Maria AsuncionChin | Zendy; Alex M. Dopico | Zendy

Open Access

Smooth Muscle Cholesterol Enables BK β1 Subunit-Mediated Channel Inhibition and Subsequent Vasoconstriction Evoked by Alcohol

Author(s) -

An. Bukiya,

Thirumalini Vaithianathan,

Guruprasad Kuntamallappanavar,

Maria AsuncionChin,

Alex M. Dopico

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.233965

Subject(s) - bk channel , vascular smooth muscle , vasoconstriction , cerebral arteries , medicine , cholesterol , endocrinology , chemistry , potassium channel , pinacidil , knockout mouse , biology , smooth muscle , glibenclamide , diabetes mellitus , receptor

Hypercholesterolemia and alcohol drinking constitute independent risk factors for cerebrovascular disease. Alcohol constricts cerebral arteries in several species, including humans. This action results from inhibition of voltage- and calcium-gated potassium channels (BK) in vascular smooth muscle cells (VSMC). BK activity is also modulated by membrane cholesterol. We investigated whether VSMC cholesterol regulates ethanol actions on BK and cerebral arteries.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research