Tissue Factor Regulates Microvessel Formation and Stabilization by Induction of Chemokine (C-C motif) Ligand 2 Expression | Zendy

Gemma Arderiu | Zendy; Esther Peña | Zendy; Rosa Aledo | Zendy; Oriol JuanBabot | Zendy; Lina Badimón | Zendy

Open Access

Tissue Factor Regulates Microvessel Formation and Stabilization by Induction of Chemokine (C-C motif) Ligand 2 Expression

Author(s) -

Gemma Arderiu,

Esther Peña,

Rosa Aledo,

Oriol JuanBabot,

Lina Badimón

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.233536

Subject(s) - microbiology and biotechnology , angiogenesis , chemokine , microvessel , tissue factor , gene silencing , chemotaxis , chemistry , vascular smooth muscle , biology , inflammation , cancer research , immunology , receptor , medicine , endocrinology , biochemistry , smooth muscle , gene , coagulation

Tissue factor (TF) triggers arterial thrombosis. TF is also able to initiate cellular signaling mechanisms leading to angiogenesis. Because high cardiovascular risk atherosclerotic plaques show significant angiogenesis, our objective was to investigate whether TF is able to trigger and stabilize atherosclerotic plaque neovessel formation.

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