Interleukin-10 Released by CD4 + CD25 + Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice | Zendy

Modar Kassan | Zendy; María Galán | Zendy; Megan Partyka | Zendy; Mohamed Trebak | Zendy; Khalid Matrougui | Zendy

Open Access

Interleukin-10 Released by CD4 ⁺ CD25 ⁺ Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice

Author(s) -

Modar Kassan,

María Galán,

Megan Partyka,

Mohamed Trebak,

Khalid Matrougui

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.233262

Subject(s) - nadph oxidase , apocynin , endocrinology , angiotensin ii , medicine , receptor antagonist , receptor , chemistry , knockout mouse , biology , antagonist , pharmacology , oxidative stress

We previously demonstrated that a reduced number of CD(4+)CD(25+)-regulatory T cells (Tregs) was associated with microvascular dysfunction in hypertension. However, the underlying mechanism by which Tregs regulate vascular endothelial function remains unknown.

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