Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis | Zendy

Seiichiro Motegi | Zendy; Wolfgang W. Leitner | Zendy; Michael Lu | Zendy; Yayoi Tada | Zendy; Miklós Sárdy | Zendy; Chuan-Jin Wu | Zendy; Triantafyllos Chavakis | Zendy; Mark C. Udey | Zendy

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Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis

Author(s) -

Seiichiro Motegi,

Wolfgang W. Leitner,

Michael Lu,

Yayoi Tada,

Miklós Sárdy,

Chuan-Jin Wu,

Triantafyllos Chavakis,

Mark C. Udey

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.232587

Subject(s) - pericyte , angiogenesis , cancer research , microbiology and biotechnology , biology , medicine , neuroscience , genetics , endothelial stem cell , in vitro

MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial growth factor-dependent angiogenesis. Major sources of MFG-E8 in vivo and precise mechanisms of MFG-E8 action remain undetermined. The objective of this study was to identify important sources of MFG-E8 in vivo and further elucidate the role(s) of MFG-E8 in the regulation of angiogenesis.

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