Premature Senescence in Cells From Patients With Autosomal Recessive Hypercholesterolemia (ARH) | Zendy

Xi-Ming Sun | Zendy; Dilip D. Patel | Zendy; Juan Carlos Acosta | Zendy; Jesús Gil | Zendy; Anne K. Soutar | Zendy

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Premature Senescence in Cells From Patients With Autosomal Recessive Hypercholesterolemia (ARH)

Author(s) -

Xi-Ming Sun,

Dilip D. Patel,

Juan Carlos Acosta,

Jesús Gil,

Anne K. Soutar

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.232223

Subject(s) - mitosis , lamin , microbiology and biotechnology , clathrin , cell cycle , endocytosis , chemistry , cyclin dependent kinase 1 , biology , cell , biochemistry , nucleus

The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.

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