Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis | Zendy

Thibaut Quillard | Zendy; Yevgenia Tesmenitsky | Zendy; Kevin Croce | Zendy; Richard Travers | Zendy; Eugenia Shvartz | Zendy; Konstantinos C. Koskinas | Zendy; Galina K. Sukhova | Zendy; Elena Aïkawa | Zendy; Masanori Aikawa | Zendy; Peter Libby | Zendy

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Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis

Author(s) -

Thibaut Quillard,

Yevgenia Tesmenitsky,

Kevin Croce,

Richard Travers,

Eugenia Shvartz,

Konstantinos C. Koskinas,

Galina K. Sukhova,

Elena Aïkawa,

Masanori Aikawa,

Peter Libby

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.231563

Subject(s) - matrix metalloproteinase , collagenase , in vivo , extracellular matrix , chemistry , macrophage , fibrous cap , in vitro , matrix (chemical analysis) , pathology , interstitial collagenase , microbiology and biotechnology , biochemistry , biology , enzyme , medicine , chromatography

Evidence has linked collagen loss with the onset of acute coronary events. This study tested the hypothesis that selective matrix metalloproteinase-13 (MMP-13) collagenase inhibition increases collagen content in already established and nascent mouse atheromas.

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