CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice | Zendy

Marjorie Poggi | Zendy; David Engel | Zendy; Anette Christ | Zendy; Linda Beckers | Zendy; Erwin Wijnands | Zendy; Louis Boon | Zendy; Ann Driessen | Zendy; Jack P.M. Cleutjens | Zendy; Christian Weber | Zendy; Norbert Gerdes | Zendy; Esther Lutgens | Zendy

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CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

Author(s) -

Marjorie Poggi,

David Engel,

Anette Christ,

Linda Beckers,

Erwin Wijnands,

Louis Boon,

Ann Driessen,

Jack P.M. Cleutjens,

Christian Weber,

Norbert Gerdes,

Esther Lutgens

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.231357

Subject(s) - adipose tissue , inflammation , insulin resistance , endocrinology , immune system , medicine , metabolic syndrome , cd40 , biology , obesity , immunology , cytotoxic t cell , biochemistry , in vitro

Obese adipose tissue shows hallmarks of chronic inflammation, which promotes the development of metabolic disorders. The mechanisms by which immune cells interact with each other or with metabolism-associated cell types, and the players involved, are still unclear. The CD40-CD40L costimulatory dyad plays a pivotal role in immune responses and in diseases such as atherosclerosis and may therefore be a mediator of obesity. Here we investigated whether CD40L is involved in adipose tissue inflammation and its associated metabolic changes.

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