C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway | Zendy

Qijun Zheng | Zendy; Yuexing Yuan | Zendy; Wei Yi | Zendy; Wayne Bond Lau | Zendy; Yajing Wang | Zendy; Xiaoliang Wang | Zendy; Yang Sun | Zendy; Bernard L. Lopez | Zendy; Theodore A. Christopher | Zendy; Jonathan M. Peterson | Zendy; G. William Wong | Zendy; Shiqiang Yu | Zendy; Dinghua Yi | Zendy; Xin-Liang Ma | Zendy

Open Access

C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway

Author(s) -

Qijun Zheng,

Yuexing Yuan,

Wei Yi,

Wayne Bond Lau,

Yajing Wang,

Xiaoliang Wang,

Yang Sun,

Bernard L. Lopez,

Theodore A. Christopher,

Jonathan M. Peterson,

G. William Wong,

Shiqiang Yu,

Dinghua Yi,

Xin-Liang Ma

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.231050

Subject(s) - adipokine , ampk , adiponectin , enos , nitric oxide , endocrinology , medicine , adiponectin receptor 1 , signal transduction , chemistry , receptor , nitric oxide synthase , protein kinase a , diabetes mellitus , biochemistry , insulin resistance , kinase

Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest systemic dysfunction unless metabolically challenged. The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as APN paralogs and some CTRP members share APN's metabolic regulatory function. However, the vasoactive properties of CTRPs remain completely unknown.

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