Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway | Zendy

Wei-Jan Chen | Zendy; YingHwa Chen | Zendy; KwangHuei Lin | Zendy; Chiao Hsuan Ting | Zendy; YungHsin Yeh | Zendy

Open Access

Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway

Author(s) -

Wei-Jan Chen,

YingHwa Chen,

KwangHuei Lin,

Chiao Hsuan Ting,

YungHsin Yeh

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.230987

Subject(s) - cilostazol , vascular smooth muscle , microbiology and biotechnology , medicine , endocrinology , chemistry , biology , cardiology , smooth muscle , aspirin

Cilostazol, a potent type 3 phosphodiesterase inhibitor, has recently been found to reduce neointimal formation by inhibiting vascular smooth muscle cell (VSMC) proliferation. The aim of this study is to investigate whether cilostazol exerts an action on phenotypic modulation of VSMCs, another important process in the pathogenesis of neointimal formation.

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