Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice | Zendy

Jiusong Sun | Zendy; Galina K. Sukhova | Zendy; Jie Zhang | Zendy; Han Chen | Zendy; Sara Sjöberg | Zendy; Peter Libby | Zendy; Meixiang Xiang | Zendy; Jianan Wang | Zendy; Christoph Peters | Zendy; Thomas Reinheckel | Zendy; GuoPing Shi | Zendy

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Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

Author(s) -

Jiusong Sun,

Galina K. Sukhova,

Jie Zhang,

Han Chen,

Sara Sjöberg,

Peter Libby,

Meixiang Xiang,

Jianan Wang,

Christoph Peters,

Thomas Reinheckel,

GuoPing Shi

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.230201

Subject(s) - elastase , perfusion , medicine , abdominal aortic aneurysm , aortic aneurysm , cathepsin , cardiology , aorta , pathology , chemistry , radiology , aneurysm , biochemistry , enzyme

The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. Whether this protease participates directly in AAA pathogenesis, however, is unknown.

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