Plasminogen Regulates Stromal Cell–Derived Factor-1/CXCR4–Mediated Hematopoietic Stem Cell Mobilization by Activation of Matrix Metalloproteinase-9 | Zendy

Yanqing Gong | Zendy; Yi Fan | Zendy; Jane HooverPlow | Zendy

Open Access

Plasminogen Regulates Stromal Cell–Derived Factor-1/CXCR4–Mediated Hematopoietic Stem Cell Mobilization by Activation of Matrix Metalloproteinase-9

Author(s) -

Yanqing Gong,

Yi Fan,

Jane HooverPlow

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.229583

Subject(s) - stromal cell , cxcr4 , stromal cell derived factor 1 , haematopoiesis , microbiology and biotechnology , progenitor cell , stem cell , matrix metalloproteinase , chemistry , endothelial stem cell , cancer research , biology , chemokine , receptor , biochemistry , in vitro

Granulocyte colony-stimulating factor (G-CSF) is a widespread therapeutic agent for stimulation of hematopoietic progenitor and stem cell (HPSC) mobilization from bone marrow (BM). Plasminogen (Plg) has been shown to be critical for HPSC mobilization. Here, we investigated the role of Plg in G-CSF-induced HPSC mobilization and the underlying mechanism.

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