Orally Administered Eicosapentaenoic Acid Induces Rapid Regression of Atherosclerosis Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice
Author(s) -
Kenji Nakajima,
Tomoya Yamashita,
Tomoyuki Kita,
Masafumi Takeda,
Naoto Sasaki,
Kazuyuki Kasahara,
Masakazu Shinohara,
Yoshiyuki Rikitake,
Tatsuro Ishida,
Mitsuhiro Yokoyama,
Ken–ichi Hirata
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.111.229443
Subject(s) - eicosapentaenoic acid , cd86 , medicine , cd11c , endocrinology , cd80 , cholesterol , phenotype , receptor , ldl receptor , immunology , polyunsaturated fatty acid , immune system , lipoprotein , cd40 , biology , t cell , fatty acid , cytotoxic t cell , in vitro , biochemistry , gene
Eicosapentaenoic acid (EPA) has been shown to have beneficial effects on cardiovascular diseases, although the precise mechanism is unknown. We investigated the effect of EPA on the regression of atherosclerosis.
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