Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice | Zendy

Harald Schuett | Zendy; René Oestreich | Zendy; Georg H. Waetzig | Zendy; Wijtske Annema | Zendy; Maren Luchtefeld | Zendy; Anja Hillmer | Zendy; Udo Bavendiek | Zendy; Johann von Felden | Zendy; Dimitar Divchev | Zendy; Tibor Kempf | Zendy; Kai C. Wollert | Zendy; Dirk Seegert | Zendy; Stefan RoseJohn | Zendy; Uwe J.F. Tietge | Zendy; Bernhard Schieffer | Zendy; Karsten Grote | Zendy

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Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

Author(s) -

Harald Schuett,

René Oestreich,

Georg H. Waetzig,

Wijtske Annema,

Maren Luchtefeld,

Anja Hillmer,

Udo Bavendiek,

Johann von Felden,

Dimitar Divchev,

Tibor Kempf,

Kai C. Wollert,

Dirk Seegert,

Stefan RoseJohn,

Uwe J.F. Tietge,

Bernhard Schieffer,

Karsten Grote

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.229435

Subject(s) - interleukin , immunology , medicine , inflammation , interleukin 2 , biology , cytokine

Transsignaling of interleukin (IL)-6 is a central pathway in the pathogenesis of disorders associated with chronic inflammation, such as Crohn disease, rheumatoid arthritis, and inflammatory colon cancer. Notably, IL-6 also represents an independent risk factor for coronary artery disease (CAD) in humans and is crucially involved in vascular inflammatory processes.

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