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Arginase I Attenuates Inflammatory Cytokine Secretion Induced by Lipopolysaccharide in Vascular Smooth Muscle Cells
Author(s) -
Xuping Wang,
Yuguo Chen,
Weidong Qin,
Wei Zhang,
Shujian Wei,
Juan Wang,
Fu Qiang Liu,
Lei Gong,
Feng Shuang An,
Yun Zhang,
Zheyu Chen,
Mingxiang Zhang
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.111.229302
Subject(s) - inflammation , tumor necrosis factor alpha , lipopolysaccharide , nitric oxide synthase , cytokine , downregulation and upregulation , arginase , nitric oxide , vascular smooth muscle , chemistry , macrophage , western blot , endocrinology , medicine , biology , immunology , in vitro , arginine , biochemistry , amino acid , smooth muscle , gene
Inflammation plays an important role in atherosclerosis. Arginase I (Arg I) promotes the proliferation of vascular smooth muscle cells; however, the effect of Arg I on inflammation remains unknown. The present study investigated the role of Arg I in inflammation in vitro and in vivo.

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