Inhibition of Nitric Oxide–Stimulated Vasorelaxation by Carbon Monoxide-Releasing Molecules
Author(s) -
Antonia Marazioti,
Mariarosaria Bucci,
Ciro Coletta,
Valentina Vellecco,
Padmamalini Baskaran,
Csaba Szabó,
Giuseppe Cirino,
Ana Pimenta-Marques,
Bruno H. Guerreiro,
Ana M. Gonçalves,
João Seixas,
Annie Beuve,
Carlos C. Romão,
Andreas Papapetropoulos
Publication year - 2011
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.111.229039
Subject(s) - chemistry , nitric oxide , superoxide , soluble guanylyl cyclase , carbon monoxide , biophysics , vasodilation , reactive oxygen species , biochemistry , endocrinology , enzyme , guanylate cyclase , biology , organic chemistry , catalysis
Carbon monoxide (CO) is a weak soluble guanylyl cyclase stimulator, leading to transient increases in cGMP and vasodilation. The aim of the present work was to measure the effect of CO-releasing molecules (CORMs) on the cGMP/nitric oxide (NO) pathway and to evaluate how selected CORMs affect NO-induced vasorelaxation.
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