Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo | Zendy

Masatsune Ogura | Zendy; Makoto Ayaori | Zendy; Yoshio Terao | Zendy; Tetsuya Hisada | Zendy; Maki Iizuka | Zendy; Shunichi Takiguchi | Zendy; Harumi UtoKondo | Zendy; Emi Yakushiji | Zendy; Kazuhiro Nakaya | Zendy; Makoto Sasaki | Zendy; Tomohiro Komatsu | Zendy; Hideki Ozasa | Zendy; Fumitaka Ohsuzu | Zendy; Katsunori Ikewaki | Zendy

Open Access

Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo

Author(s) -

Masatsune Ogura,

Makoto Ayaori,

Yoshio Terao,

Tetsuya Hisada,

Maki Iizuka,

Shunichi Takiguchi,

Harumi UtoKondo,

Emi Yakushiji,

Kazuhiro Nakaya,

Makoto Sasaki,

Tomohiro Komatsu,

Hideki Ozasa,

Fumitaka Ohsuzu,

Katsunori Ikewaki

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.228478

Subject(s) - abca1 , abcg1 , reverse cholesterol transport , in vivo , proteasome , cholesterol , proteasome inhibitor , microbiology and biotechnology , biology , atp binding cassette transporter , protein degradation , efflux , lipoprotein , chemistry , biochemistry , transporter , gene

ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property of high-density lipoprotein (HDL). The ubiquitin-proteasome system (UPS) mediates nonlysosomal pathways for protein degradation and is known to be involved in atherosclerosis. However, little is known about the effects of the UPS on these molecules and overall RCT. We therefore investigated whether UPS inhibition affects ABCA1/G1 expression in macrophages and RCT in vitro and in vivo.

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