An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia | Zendy

Christopher T. Johansen | Zendy; Jian Wang | Zendy; Matthew B. Lanktree | Zendy; Adam D. McIntyre | Zendy; Matthew R. Ban | Zendy; Rebecca A. Martins | Zendy; Brooke A. Kennedy | Zendy; Reina G. Hassell | Zendy; Maartje E. Visser | Zendy; Stephen M. Schwartz | Zendy; Benjamin F. Voight | Zendy; Roberto Elosúa | Zendy; Veikko Salomaa | Zendy; Christopher J. O’Donnell | Zendy; Geesje M. DallingaThie | Zendy; Sonia S. Anand | Zendy; Salim Yusuf | Zendy; Murray W. Huff | Zendy; Sekar Kathiresan | Zendy; Henian Cao | Zendy; Robert A. Hegele | Zendy

Open Access

An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia

Author(s) -

Christopher T. Johansen,

Jian Wang,

Matthew B. Lanktree,

Adam D. McIntyre,

Matthew R. Ban,

Rebecca A. Martins,

Brooke A. Kennedy,

Reina G. Hassell,

Maartje E. Visser,

Stephen M. Schwartz,

Benjamin F. Voight,

Roberto Elosúa,

Veikko Salomaa,

Christopher J. O’Donnell,

Geesje M. DallingaThie,

Sonia S. Anand,

Salim Yusuf,

Murray W. Huff,

Sekar Kathiresan,

Henian Cao,

Robert A. Hegele

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.226365

Subject(s) - hypertriglyceridemia , phenotype , allele , medicine , biology , triglyceride , genotype , genetic heterogeneity , genetics , endocrinology , cholesterol , lipoprotein , high density lipoprotein , gene

Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity.

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