Heme Induces Heme Oxygenase 1 via Nrf2 | Zendy

Joseph J. Boyle | Zendy; Michael Johns | Zendy; Jonathan W. Lo | Zendy; Alessandra Chiodini | Zendy; Nicola Ambrose | Zendy; Paul C. Evans | Zendy; Justin C. Mason | Zendy; Dorian O. Haskard | Zendy

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Heme Induces Heme Oxygenase 1 via Nrf2

Author(s) -

Joseph J. Boyle,

Michael Johns,

Jonathan W. Lo,

Alessandra Chiodini,

Nicola Ambrose,

Paul C. Evans,

Justin C. Mason,

Dorian O. Haskard

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.225813

Subject(s) - heme , heme oxygenase , cd163 , small interfering rna , cycloheximide , oxidative stress , chemistry , microbiology and biotechnology , downregulation and upregulation , macrophage , reactive oxygen species , biology , biochemistry , rna , protein biosynthesis , in vitro , gene , enzyme

Intraplaque hemorrhage (IPH) is an important progression event in advanced atherosclerosis, in large part because of the delivery of prooxidant hemoglobin in erythrocytes. We have previously defined a novel macrophage phenotype (hemorrhage-associated-mac) in human advanced plaques with IPH. These may be atheroprotective in view of raised heme oxygenase 1 (HO-1), CD163, and interleukin-10 expression and suppressed oxidative stress.

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