Matrix Metalloproteinase (MMP)-3 Activates MMP-9 Mediated Vascular Smooth Muscle Cell Migration and Neointima Formation in Mice | Zendy

Jason L. Johnson | Zendy; Amrita Dwivedi | Zendy; Michelle Somerville | Zendy; Sarah J. George | Zendy; Andrew C. Newby | Zendy

Open Access

Matrix Metalloproteinase (MMP)-3 Activates MMP-9 Mediated Vascular Smooth Muscle Cell Migration and Neointima Formation in Mice

Author(s) -

Jason L. Johnson,

Amrita Dwivedi,

Michelle Somerville,

Sarah J. George,

Andrew C. Newby

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.225623

Subject(s) - neointima , matrix metalloproteinase , knockout mouse , vascular smooth muscle , cell migration , microbiology and biotechnology , extracellular matrix , gene knockdown , chemistry , cell , biology , medicine , endocrinology , restenosis , receptor , apoptosis , biochemistry , smooth muscle , stent

Several matrix metalloproteinases (MMPs) have been implicated in extracellular matrix destruction and other actions that lead to plaque rupture and myocardial infarction. Conversely, other MMPs have been shown to promote vascular smooth muscle cell (VSMC)-driven neointima formation, which contributes to restenosis, fibrous cap formation, and plaque stability. MMP-3 knockout reduced VSMC accumulation in mouse atherosclerotic plaques, implicating MMP-3 in neointima formation. We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research