Neointima Formed by Arterial Smooth Muscle Cells Expressing Versican Variant V3 Is Resistant to Lipid and Macrophage Accumulation | Zendy

Mervyn J. Merrilees | Zendy; Brent Beaumont | Zendy; Kathleen R. Braun | Zendy; Anita C. Thomas | Zendy; Inkyung Kang | Zendy; Aleksander Hinek | Zendy; Alberto Passi | Zendy; Thomas N. Wight | Zendy

Open Access

Neointima Formed by Arterial Smooth Muscle Cells Expressing Versican Variant V3 Is Resistant to Lipid and Macrophage Accumulation

Author(s) -

Mervyn J. Merrilees,

Brent Beaumont,

Kathleen R. Braun,

Anita C. Thomas,

Inkyung Kang,

Aleksander Hinek,

Alberto Passi,

Thomas N. Wight

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.225573

Subject(s) - neointima , versican , macrophage , vascular smooth muscle , smooth muscle , microbiology and biotechnology , chemistry , anatomy , extracellular matrix , medicine , biology , biochemistry , restenosis , in vitro , proteoglycan , stent

Extracellular matrix (ECM) of neointima formed following angioplasty contains elevated levels of versican, loosely arranged collagen, and fragmented deposits of elastin, features associated with lipid and macrophage accumulation. ECM with a low versican content, compact structure, and increased elastic fiber content can be achieved by expression of versican variant V3, which lacks chondroitin sulfate glycosaminoglycans. We hypothesized that V3-expressing arterial smooth muscle cells (ASMC) can be used to form a neointima resistant to lipid and macrophage accumulation associated with hypercholesterolemia.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research