Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells | Zendy

José Castellano | Zendy; Rosa Aledo | Zendy; J. Sendra | Zendy; Paula Costales | Zendy; Oriol JuanBabot | Zendy; Lina Badimón | Zendy; Vicenta LlorenteCortés | Zendy

Open Access

Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells

Author(s) -

José Castellano,

Rosa Aledo,

J. Sendra,

Paula Costales,

Oriol JuanBabot,

Lina Badimón,

Vicenta LlorenteCortés

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.225490

Subject(s) - lrp1 , hypoxia (environmental) , downregulation and upregulation , ldl receptor , western blot , vascular smooth muscle , microbiology and biotechnology , biology , hypoxia inducible factors , lipoprotein , chemistry , endocrinology , medicine , biochemistry , cholesterol , gene , oxygen , organic chemistry , smooth muscle

Hypoxia is considered a key factor in the progression of atherosclerotic lesions. Low-density lipoprotein receptor-related protein (LRP1) plays a pivotal role in the vasculature. The aim of this study was to investigate the effect of hypoxia on LRP1 expression and function in vascular smooth muscle cells (VSMC) and the role of hypoxia-inducible factor-α (HIF-1α).

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