Assessing Low Levels of Mechanical Stress in Aortic Atherosclerotic Lesions From Apolipoprotein E −/− Mice—Brief Report | Zendy

Alexis Broisat | Zendy; Jakub Toczek | Zendy; Nicolas Mesnier | Zendy; Philippe Tracqui | Zendy; Cathérine Ghezzi | Zendy; Jacques Ohayon | Zendy; Laurent Riou | Zendy

Open Access

Assessing Low Levels of Mechanical Stress in Aortic Atherosclerotic Lesions From Apolipoprotein E ^−/− Mice—Brief Report

Author(s) -

Alexis Broisat,

Jakub Toczek,

Nicolas Mesnier,

Philippe Tracqui,

Cathérine Ghezzi,

Jacques Ohayon,

Laurent Riou

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.225227

Subject(s) - apolipoprotein e , pathology , apolipoprotein b , aortic arch , medicine , aorta , fibrous cap , pathological , cholesterol , disease

Despite the fact that mechanical stresses are well recognized as key determinants for atherosclerotic plaque rupture, very little is known about stress amplitude and distribution in atherosclerotic lesions, even in the standard apolipoprotein E (apoE)-/- mouse model of atherosclerosis. Our objectives were to combine immunohistology, atomic force microscopy measurements, and finite element computational analysis for the accurate quantification of stress amplitude and distribution in apoE-/- mouse aortic atherosclerotic lesions.

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