The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow | Zendy

Mariela Sivina | Zendy; Takeshi Yamada | Zendy; Chun Shik Park | Zendy; Monica Puppi | Zendy; Süleyman Coşkun | Zendy; Karen K. Hirschi | Zendy; H. Daniel Lacorazza | Zendy

Open Access

The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow

Author(s) -

Mariela Sivina,

Takeshi Yamada,

Chun Shik Park,

Monica Puppi,

Süleyman Coşkun,

Karen K. Hirschi,

H. Daniel Lacorazza

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.224436

Subject(s) - bone marrow , cd31 , biology , endothelial stem cell , haematopoiesis , cancer research , microbiology and biotechnology , progenitor cell , transcription factor , stem cell , immunology , angiogenesis , gene , in vitro , biochemistry

The regeneration of the hematopoietic system in bone marrow after chemotherapy depends on a balance between the quiescence and proliferation of lineage-specific progenitor cells. Even though the vascular network in bone is damaged by cytoablation, the transcriptional control of quiescence in endothelial cells is not well known. In this study, we investigated the role of the transcription factor E74-like factor (ELF4) in the proliferation of endothelial cells in bone marrow.

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