Inhibition of Pathological Differentiation of Valvular Interstitial Cells by C-Type Natriuretic Peptide | Zendy

Cindy Ying Yin Yip | Zendy; Mark C. Blaser | Zendy; Zahra Mirzaei | Zendy; Xiao Zhong | Zendy; Craig A. Simmons | Zendy

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Inhibition of Pathological Differentiation of Valvular Interstitial Cells by C-Type Natriuretic Peptide

Author(s) -

Cindy Ying Yin Yip,

Mark C. Blaser,

Zahra Mirzaei,

Xiao Zhong,

Craig A. Simmons

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.223974

Subject(s) - myofibroblast , microbiology and biotechnology , paracrine signalling , autocrine signalling , osteoblast , cellular differentiation , endocrinology , simvastatin , medicine , chemistry , biology , receptor , fibrosis , in vitro , biochemistry , gene

Calcific aortic valve disease is associated with the differentiation of valvular interstitial cells (VICs) to myofibroblast and osteoblast-like cells, particularly in the fibrosa layer of the valve. Previous studies suggested that C-type natriuretic peptide (CNP) protects against calcific aortic valve disease to maintain homeostasis. We aimed to determine whether CNP inhibits VIC pathological differentiation as a mechanism to explain its protective effects.

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