SDF-1α Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation | Zendy

Raphael A. Nemenoff | Zendy; Henrick Horita | Zendy; Allison C. Ostriker | Zendy; Seth B. Furgeson | Zendy; Peter Simpson | Zendy; Vicki VanPutten | Zendy; Joseph T. Crossno | Zendy; Stefan Offermanns | Zendy; Mary C.M. WeiserEvans | Zendy

Open Access

SDF-1α Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation

Author(s) -

Raphael A. Nemenoff,

Henrick Horita,

Allison C. Ostriker,

Seth B. Furgeson,

Peter Simpson,

Vicki VanPutten,

Joseph T. Crossno,

Stefan Offermanns,

Mary C.M. WeiserEvans

Publication year - 2011

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.223701

Subject(s) - neointima , mediator , pten , microbiology and biotechnology , chemistry , cancer research , smooth muscle , inflammation , signal transduction , medicine , biology , pi3k/akt/mtor pathway , restenosis , stent

PTEN inactivation selectively in smooth muscle cells (SMC) initiates multiple downstream events driving neointima formation, including SMC cytokine/chemokine production, in particular stromal cell-derived factor-1α (SDF-1α). We investigated the effects of SDF-1α on resident SMC and bone marrow-derived cells and in mediating neointima formation.

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